Increasingly higher dosages of isotretinoin will result in higher toxicity, resembling vitamin A toxicity (the higher the dosage, the more pronounced the side effects will be). The "upper limit" for Vitamin A (Retinol) is 3 milligrams (10,000 IU). This is the dosage at which the scientific community agrees there are no side effects for Vitamin A. Isotretinoin is available in 2.5mg capsules (as well as 5mg, 10mg, 20mg, 40mg). However, isotretinoin is more teratogenic (causes birth defects) than vitamin A at the same dosage<citation>needed].
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Some people develop headaches while on Accutane. These respond to Advil or Tylenol. If a persistent headache develops while on Accutane, the medication should be stopped and the physician notified. Accutane has been reported to cause depression and thoughts of suicide, though a recent study has not shown any correlation. Extremely vigorous exercise should be avoided, as muscle aches can develop.
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Psychiatric: suicidal ideation, suicide attempts, suicide, depression, psychosis, aggression, violent behaviors (see WARNINGS: Psychiatric Disorders), emotional instability